Dr. Öğr. Üyesi
Ali Tuğrul Akin
Tıbbi Biyoloji
H-Index: 10
Dr. Ali Tuğrul Akin, 2012 yılında Erciyes Üniversitesi Fen Fakültesi Biyoloji Bölümü’nden mezun olmuştur. Yüksek lisansını aynı üniversitenin Fen Bilimleri Enstitüsü’nde tamamladıktan sonra, 2021 yılında “Adriamycin ile İndüklenen Testis Hasarında Pluripotensinin Histolojik ve Moleküler Bakımdan İncelenmesi” başlıklı tezi ile doktora derecesini almıştır. Doktora sonrası araştırmalarının bir bölümünü Erciyes Üniversitesi İlaç Uygulama ve Araştırma Merkezi (ERFARMA) bünyesinde kurduğu laboratuvar ve araştırma ekibi ile yürütmüştür. 2023 yılında TÜBİTAK 2219 Yurtdışı Doktora Sonrası Araştırma Bursu kapsamında King’s College London’da doktora sonrası araştırmalar gerçekleştirmiştir. 2024 yılında aynı üniversitenin Cancer and Pharmaceutical Science bölümünde postdoctoral researcher olarak görev almış ve Kronik Lenfositik Lösemi (CLL) ve Akut Promyelositik Lösemi (APL) üzerine araştırmalar yapmıştır. Çalışmaları, kanser epigenetiği, epigenetik modifikasyonlar, DNA hasarı ve replikasyonu ile farmasötik ilaç hedefleri üzerine yoğunlaşmaktadır.
Araştırma Alanları
- Kanser Epigenetiği
- Moleküler Biyoloji
- Akut ve kronik lösemiler
- DNA Hasarı Tespit Yöntemleri Genotoksisite
- Farmakoloji
Çalışma Alanları
- Sağlık Bilimleri Temel Alanı
- Tıbbi Biyoloji
- Unveiling the Protective Potential of Crocin in Septic Acute Liver Injury via Assessment of TLR4/HGM1/NF‐κB Signaling Pathway, Oxidative Stress and Heat Shock Response, 2025
- Effect of propolis supplementation on cadmium toxicity associated with renal and hepatic dysfunction in rats, 2025
- Effect of thymoquinone on NRF2/NF-kB/MAPK pathway in methotrexate-induced rat testis injury, 2024
- Research on the Effects of the Juncus Inflexus Subsp. Inflexus Extract on Low Dose Thioacetamide‐Induced Liver Damage: A Novel Antioxidant, 2024
- The Research on Endoplasmic Reticulum Stress-mediated Protective Effect of Melatonin against Cardiotoxicity Following Cisplatin Treatment, 2024
- Crocin Suppresses Inflammatory Response in LPS-Induced Acute Lung Injury (ALI) Via Regulation of HMGB1/TLR4 Inflammation Pathway, 2024
- Effect of vitamin B12 on methotrexate-induced cardiotoxicity in rats, 2024
- Effects of adriamycin on cell differentiation and proliferation in rat testis, 2023
- In vivo Gonadoprotective Effects of Myricetin on Cisplatin- Induced Testicular Damage via Suppression of TLR4/NF-kB Inflammation Pathway and Heat-Shock Response, 2023
- Thymoquinone reduces methotrexate-induced heart damage: a histopathological study in rats, 2023
- Protective effect of melatonin on cisplatin induced acute kidney injury: Role of regulation of heat shock proteins expressions, 2023
- Histopathological Changes In Lung Tissue Caused By Diabetes: A Review, 2023
- Investigation of the effect of thymoquinone on kidney damage in isoproterenol-induced myocardial infarction in rats and cardiorenal interactions, 2023
- Thymoquinone attenuates doxorubicin-induced lung damage via heat shock proteins, inflammation and endoplasmic reticulum stress, 2023
- Therapeutic effect of thymoquinone on brain damage caused by nonylphenol exposure in rats, 2023
- Immunoreactivity of Kir3.1, muscarinic receptors 2 and 3 on the brainstem, vagus nerve and heart tissue under experimental demyelination, 2023
- Protective effect of melatonin on cisplatin-induced liver injury in rats, 2022
- The protective effect of Origanum majorana essential oil on gentamicin-induced nephrotoxicity in rats., 2022
- Histopathological Changes In Lung Tissue Caused By Diabetes: A Review, 2022
- Investigation of the effect of Chloroquine on Adriamycin-induced kidney damage, 2022
- Vitamin B12 Alleviates Methotrexate-Induced Lung Injury In Rat: A Histopathological, Immunohistochemical, and Biochemical Study., 2022
- Probiotic supplementation alleviates absence seizures and anxiety- and depression-like behavior in WAG/Rij rat by increasing neurotrophic factors and decreasing proinflammatory cytokines, 2022
- Thymoquinone alleviates doxorubicin induced acute kidney injury by decreasing endoplasmic reticulum stress, inflammation and apoptosis, 2022
- Anti-inflammatory and anti-apoptotic effects of naringin on bacterial endotoxin-induced small intestine damage in rats, 2022
- Chloroquine Decreased Kir6.2 Immunoreactivity in Chronic Hypoxic Heart, 2022
- Electrophysiological, histopathological and biochemical evaluation of the protective effect of probiotic supplementation against PTZ\u2010induced seizures in rats, 2022
- Chloroquine attenuates chronic hypoxia\u2010induced testicular damage via suppressing endoplasmic reticulum stress and apoptosis in experimental rat model, 2022
- Mitigative effects of chloroquine treatment against hypoxia-induced intestinal injury: a histological and immunohistochemical study., 2022
- Thymoquinone attenuates doxorubicin-cardiotoxicity in rats, 2021
- The effect of chloroquine on the TRPC1, TRPC6, and CaSR in the pulmonary artery smooth muscle cells in hypoxia-induced experimental pulmonary artery hypertension, 2021
- L-Carnitine ameliorates the liver by regulating alpha-SMA, iNOS, HSP90, HIF-1alpha, and RIP1 expressions of CCL4-toxic rats, 2021
- The Ameliorative Effects of Caffeic Acid Phenethyl Ester in Cisplatin-Induced Nephrotoxicity: Assessment of the Oxidative Stress an Inflammation, 2021
- Vitamin B12 Regulates the Expression of Methotrexate-Induced Increased Markers of Autophagy: An Immunohistochemical Study, 2021
- Investigation of the Therapeutic Effects of Chloroquine in Adriamycin-Induced Hepatotoxicity, 2021
- The Effects of Rapamycin and 3-Methyladenine on Nitric Oxide Synthase Enzymes in Cisplatin-Induced Neurotoxicity, 2021
- Chloroquine Ameliorates Adriamycin-Induced Testicular Damage by Suppressing the Inflammation and Apoptosis in Rats: A Histological, Immunohistochemical and Biochemical Study, 2021
- Thymoquinone has a neuroprotective effect against inflammation, oxidative stress, and endoplasmic reticulum stress in the brain cortex, medulla, and hippocampus due to doxorubicin, 2021
- Vitamin B12 suppresses GADD153, prevents apoptosis and regulates the testicular function in methotrexate treated rat testis, 2021
- Therapeutic effects of thymoquinone in doxorubicin-induced hepatotoxicity via oxidative stress, inflammation and apoptosis, 2021
- Evaluation by different mechanisms of the protective effects of vitamin B12 on methotrexate nephrotoxicity, 2021
- Histological evaluation of the effects of rapamycin and 3-methyladenine on cisplatin-induced epididymal injury in rats, 2021
- Lipopolisakkarit’in neden olduğu bağırsak toksisitesine karşı biyosentetik gümüş nanopartiküllerin etkisi, 2020
- Effects of vitamin B12 on methotrexate hepatotoxicity: evaluation of receptor-interacting protein (RIP) kinase, 2020
- Comparison of the Acute and Cumulative Dose Administrations in Doxorubicin-induced Hepatotoxicity via Evaluation of the Histopathological Changes and Inflammation in Rats, 2020
- Etilen Glikolun Mide Uzerine Etkisi: Histolojik Calısma, 2020
- L-carnitine effects in CCl4-nephrotoxicity: Immunohistochemical evaluation of glomerular nephrin and HIF-1alpha expressions, 2020
- Effects of Melatonin Against Thioacetamide-Induced Testicular Toxicity in Rats, 2020
- Chloroquine inhibits adriamycin-induced cardiotoxicity in rats by inhibiting endoplasmic reticulum stress and inflammation, 2020
- Histological Examination of Rat Heart Tissue withChronic Diabetes, 2020
- Thymoquinone is a protective agent that reduces the negative effects of doxorubicin in rat testis, 2020
- GÜMÜŞ NANOPARTİKÜLLERİNİN ÜZÜM ÇEKİRDEĞİ EKSTRAKTININ ENDOTOKSİK KALP DOKUSUNDAKİ HİSTOLOJİK DEĞİŞİKLERE VE TNF-ɑ VE BNP EKSPRESYONUNA ETKİSİ, 2019
- Apilarnilin'in erkek sıçanlarda Lipopolisakkarite (LPS) bağlı testis toksisitesine karşı koruyucu rolünün belirlenmesi , 2019
- Oribatid mite fauna (Acari) of the Çat Forest (Sivas, Turkey), 2017
- Türkiye akar faunası için yeni bir kayıt Eremobelba geographica Berlese 1908 Acari Oribatida, 2015
- Chloroquine Improves Adriamycin-Induced Brain Injury By Reducing Endoplasmic Reticulum Stress,
- Crocin Suppresses Inflammatory Response in LPS-Induced Acute Lung Injury (ALI) Via Regulation of HMGB1/TLR4 Inflammation Pathway,
- Sivas Çat Ormanları'nın Oribatid Akar Faunası (Acari, Oribatida),
- Türkiye akar faunası için yeni bir kayıt Eremobelba geographica Berlese 1908 Acari Oribatida, 2014
- Karbon Tetraklorür İle Oluşturulan Testis Hasarında Isı Şok Protein Yoğunlukları Üzerine Karnozinin Etkisi, 2018
- Inlammation in Doxorubicin-induced Testis Injury, 2018
- ANTI-INFLAMMATORY EFFECTS OF CROCIN IN LPS-INDUCED BOWEL DAMAGE VIA SUPPRESSION OF TLR4 EXPRESSION, 2022
- EFFECT OF THYMOQUINONE ON METHOTREXATE-INDUCED RAT TESTICULAR INJURY, 2022
- Investigation of the effect of grape seed, silver nitrate and silver nanoparticle on kidney damage induced by lipopolysaccharide (LPS), 2019
- Effects of Grayanatoxin (GTX III) on BNP Expression in Rat Heart Tissue, 2018
- Effect of chloroquine in hypoxia-induced bowel damage, 2019
- Kronik Hipoksiye Maruz Bırakılan Ratlardaki Mide Ghrelin Miktarı Uzerine Klorokuin’in Etkisi, 2019
- Metotreksat-kaynaklı Akciger Hasarında B12 vitamini etkisinin degerlendirilmesi, 2020
- Sisplatin-induklenmis Sıcanların Epididimis Dokusunun Degerlendirilmesi, 2020
- Role of Inflammation in Acute and Chronic Adriamycin-induced Nephropathy, 2018
- The Dose-dependent Effects of Doxorubicin in Rat Liver Tissue,
- The Effects of Doxorubicin Administered Acute and Cronic Doses On Heart Tissue in Rats,
- Advances in Health Sciences, ISBN: 978-625-8109-18-4, 2022
- Research & Reviews in Health Sciences - I, ISBN: 978-625-8002-42-3, 2021
- Güncel Fizyoloji-Histoloji-Embriyoloji Çalışmaları-II, ISBN: 978-625-8430-11-0, 2021
- En iyi sözlü sunum ödülü, 2023