Dr. Yelda Birinci graduated with her bachelor’s degree from Dokuz Eylül University, Department of Biology. She has done her masters in Medical Biology and Genetic (2007) and PhD degree in Medical Biochemistry from Karadeniz Technical University, Medicine Faculty, Basic Sciences (2014). Dr. Birinci joined Bioenergetics Laboratory in Biochemistry Department of Bologna University as a visiting researcher for her doctorate thesis supervised by Dr. Maria Luisa Genova. The main scope was the analysis of the kinetic properties of the respiratory supercomplex I-III and the role of its redox intermediate, Coenzyme Q10 in mammalian mitochondria and proteoliposome models. After her doctorate, she directly started working as a Postdoc in Molecular Biology, Genetics and Bioengineering Department at Sabanci University. She worked on the development of nano-based drug delivery system and expanded her research horizons with interdisciplinary research by integrating materials sciences innovation with molecular biology. She developed a nano-antioxidant which worked efficiently on preventing and recovering oxidative damage in cells. This invention was registered European Patent Office on 2018, and it has been published with the number of WO2018124994A1 on 2022. She has worked at Koc University as a senior postdoctoral researcher for 2018-2020 in the EMBO project of Dr. Yongsoo Park. The project concerns miRNA exocytosis by large dense core (LDCV) vesicle fusion in neurotransmission. She has been working as an Assistant Professor at Medical Biochemistry Department of Istinye University since 2021.
Araştırma Alanları
- Nano Mikro Teknolojilerin Klinik Uygulamaları
- Nanopartiküler Sistemler
- Mitochondrial Medicine
- Mitochondrial Supercomplexes
- Theranostic Therapy
- Oxidative Stress
Çalışma Alanları
- Sağlık Bilimleri Temel Alanı
- Tıbbi Biyokimya
- Role of Exosomal MicroRNAs in Cell-to-Cell Communication, 2021
- Isolation of large dense-core vesicles from bovine adrenal medulla for functional studies, 2020
- Quercetin in the form of a nano-antioxidant (QTiO2) provides stabilization of quercetin and maximizes its antioxidant capacity in the mouse fibroblast model, 2020
- Role of mTORC1 and mTORC2 in Breast Cancer: Therapeutic Targeting of mTOR and Its Partners to Overcome Metastasis and Drug Resistance, 2019
- Augmented mitochondrial cytochrome c oxidase activity in children with iron deficiency: a tandem between iron and copper?, 2018
- Involvement ofDFNB59 mutations in autosomal recessive nonsyndromic hearing impairment, 2007
- Development of Microfabricated Tools to Investigate Immune Cell-Tumor Cell Interactions, 2016
- Modulation of ROS production plasticity of respiratory supercomplexes: a possible mechanism of intracellular signaling,
- Kinetic properties of Supercomplex I1III2 reconstituted in vitro. 5th World Congress on Targeting Mitochondria.,
- Coenzyme Q in the mitochondrıal respiratory chain: inter-enzyme channeling vs. pool behaviour,
- Mitochondrial Respiratory Chain Supercomplexes limit ROS production. 8th Forum on Oxidative Stress and Aging.,
- Mitochondrial respiratory supercomplexes: kinetic advantage and ROS production,
- Methods in Molecular Biology, ISBN: 9781071611708, 2021
- Advances Experimental Medical Biology, ISBN: 978-3-030-20300-9, 2019